The Bruker DRX400
The DRX400 is a 9.4 Tesla multinuclear instrument with micro imaging capabilities. The triple axis gradients enable localized spectroscopy, diffusion measurements and microimaging. The system allows 1H, 31P, 13C, 23Na and 19F spectroscopy of mammalian cell utilizing biorector technology. This spectrometer is equipped with 5mm, 10mm and 20mm probes.
Imaging Probes
- Micro-imaging probe with exchangeable resonators from 2.5 - 30 mm ID
- Mouse probe for mice up to 30g
- Gradient Strength 2.5G/cmA - max 100G/cm
- Biorector accessories for 5 and 10mm
Standard Probes
- 5,10,20 and 25 mm standard probes for all nuclei
Current Applications
- Measurement and regulation of pH in tumors and cultured cells
- Tumor and tissue perfusion measurements
- Diffusion of water in tumors and cultured cells
- Metabolism of polyamines in tumors and tumor cells
- Regulation of phosphomonoester metabolism in cells and tumors
- Use of MRI and MRS to monitor response of tumors to chemotherapy
- Microimaging of embryos in vivo
- Imaging of transgenic mice
